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小柴胡汤是中国古代经典名方，具有清解邪热、培补正气、畅利枢机、安和脾胃、疏达三焦、宣通内外等作用，其所含化学成分种类繁多，且具有多种药理活性成分，通过多种通路和靶点对多种肿瘤产生周期阻滞，抑制血管生成，诱导自噬、凋亡、焦亡以及铁死亡等作用，还能增强人体的免疫力，治疗或辅助治疗各种癌症的并发症。本文对小柴胡汤及其潜在活性成分的抗肿瘤作用及机制进行综述，以期为小柴胡汤抗肿瘤的深入研究提供参考。
Abstract：Xiaochaihu decoction, a classical prescription in traditional Chinese medicine, has multiple therapeutic effects, including clearing pathogenic heat, strengthening vital Qi, harmonizing the spleen and stomach, regulating the three burners, and promoting the circulation of internal and external pathways. It contains many chemical constituents with diverse pharmacological activities. These active components act through multiple pathways and targets to induce the cell cycle arrest, inhibit angiogenesis, and trigger autophagy, apoptosis, pyroptosis, and ferroptosis in tumors. Moreover, Xiaochaihu decoction enhances the immune function and can adjuvantly manage cancer-related complications. This review summarizes the antitumor effect and mechanism of Xiaochaihu decoction and its potential active constituents, providing a reference for further research on its antitumor potential.
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基本信息:
中图分类号:R285
引用信息:
[1]张龙,邱亿鸿,宿洪兵,等.小柴胡汤抗肿瘤作用研究进展及潜在活性成分[J].中南药学,2026,24(02):191-195.
基金信息:
黑龙江自然科学基金联合引导项目（No.LH2022H085）; 黑龙江省中医药科研项目（No.ZHY2022-111）
2026-02-20
2026-02-20