| 5,548 | 207 | 274 |
| 下载次数 | 被引频次 | 阅读次数 |
山楂是我国的特产果树,其栽培和应用的历史悠久,是药食两用的上等补品。临床主要用于心脑血管系统及消化系统疾病,更是最常用的减肥及辅助降血脂保健品原料之一。近年来山楂在调节血脂、抗癌、增强免疫力、抗氧化方面的药理作用备受关注,本文针对这几方面的文献进行综述,根据不同的作用机制对山楂的有效部位、成分及其作用靶点进行分析和总结。结果发现山楂药效明确,且有多靶点的作用特点,必将具有广阔的应用前景。
Abstract：China has a long history of cultivation and application of hawthorn, whose fruits are top class tonic with edible and medical use. Hawthorn is mainly used in cardiocerebral vascular and digestive system disease. At the same time, it is one of the most common forms of raw materials of healthcare products with weight-losing and blood lipidreducing function. In recent years, more and more attention has been paid to the blood lipid regulation, anti-tumor, immunity-boosting and antioxidation effect of hawthorn. In this paper, we summarized the research progress of these pharmacological activities. The effective parts, components, and targets were analyzed and summarized based on the basis of different actions. In a word, hawthorn has multiple target points and definite efficacy. It will be more and more widely applied in medicine and healthcare.
[1]中国药典2010年版.一部[S].2010:29.
[2]Jurikova T,Sochor J,Rop O,et al.Polyphenolic profi le and biological activity of Chinese hawthorn(Crataegus pinnatifi da BUNGE)fruits[J].Molecules,2012,17(12):14490-14509.
[3]孟庆杰,王光全,张丽.山楂功能因子及其保健食品的开发利用[J].食品科学,2006,27(12):873-877.
[4]Zhang Z,Ho WK,Huang Y,et al.Hawthorn fruit is hypolipidemic in rabbits fed a high cholesterol diet[J].J Nutr,2002,132(1):5-10.
[5]Lin Y,Vermeer MA,Trautwein EA.Triterpenic acids present in hawthorn lower plasma cholesterol by inhibiting intestinal ACAT activity in hamsters[J].Evid Based Complement Alternat Med,2011,2011:801272.doi:10.1093/ecam/nep007.
[6]李贵海,孙敬勇,张西林,等.山楂降血脂有效成分的实验研究[J].中草药,2002,33(1):50.
[7]刘北林,董继生,倪小虎,等.山楂黄酮提取及降血脂研究[J].食品科学,2007,28(5):324-327.
[8]Ye XL,Huang WW,Chen Z,et al.Synergic effect and structure-activity relationship of 3-hydroxy-3-methylglutaryl Coenzyme A reductase inhibitors from Crataegus pinnatifidaBge[J].J Agric Food Chem,2010,58(5):3132-3138.
[9]范学辉,张清安,胡柏平,等.有氧运动与山楂籽油干预对高脂饮食大鼠脂代谢、抗氧化能力及内皮细胞功能的影响[J].陕西师范大学学报:自然科学版,2011,39(4):103-108.
[10]林秋实,陈吉棣.山楂及山楂黄酮预防大鼠脂质代谢紊乱的分子机制研究[J].营养学报,2000,22(2):131.
[11]Rajendran S,Deepalakshmi PD,Parasakthy K,et al.Effect of tincture of Crataegus on the LDL-receptor activity of hepatic plasma membrane of rats fed an atherogenic diet[J].Atherosclerosis,1996,123(1-2):235-241.
[12]Zhang ZS,Ho WKK,Huang Y,et al.Hypocholesterolemic activity of hawthorn fruit is mediated by regulation of cholesterol-7 alpha-hydroxylase and acyl Co A:Cholesterol acyltransferase[J].Food Res Int,2002,35(9):885-891.
[13]Niu CS,Chen CT,Chen LJ,et al.Decrease of blood lipids induced by Shan-Zha(fruit of Crataegus pinnatifida)is mainly related to an increase of PPAR alpha in liver of mice fed high-fat diet[J].Horm Metab Res,2011,43(9):625-630.
[14]刘新迎,周联.通过对3T3-L1细胞的作用探讨山楂叶总黄酮调脂机制[J].中华中医药学刊,2009,27(5):1066-1068.
[15]葛喜珍,林强,霍清,等.大豆异黄酮及其山楂复方对高脂血症大鼠血栓形成的影响[J].中药药理与临床,2006,22(6):42-43.
[16]柳军,王雪,罗丹,等.五环三萜抑制A549细胞生长与促进糖原累积作用的相关性研究[J].中国新药杂志,2011,20(23):2350-2353.
[17]张妍,李厚伟,孙建平,等.山楂果总黄酮的提取分离及体外抗肿瘤活性[J].中草药,2004,35(7):787-789.
[18]董贺,张太平,李俊,等.山楂中谷甾醇抑制肿瘤细胞的研究[J].中国生化药物杂志,2009,30(4):270-272.
[19]林科,张太平,朱顺,等.山楂熊果酸的制备及对小鼠免疫功能和肝癌细胞凋亡的影响[J].中国生化药物杂志,2007,28(5):308-311.
[20]李敏芳,李慧,王学美.金丝桃苷药理作用研究进展[J].中国中医药信息杂志,2008,15(4):102-104.
[21]Hahn SM,Sullivan FJ,Deluea AM,et al.Evaluation of tempol radioprotection in a murine tumor mode[J].Free Radic Biol Med,1997,22(7):1211.
[22]Chu CY,Lee MJ,Liao CL,et al.Inhibitory effect of hotwater extract from dried fruit of Crataegus pinnatifi da on lowdensity lipoprotein(LDL)oxidation in cell and cell-free systems[J].J Agric Food Chem,2003,51(26):7583-7588.
[23]Li C,Son H J,Huang C,et al.Comparison of Crataegus pinnatifida Bunge var.typica Schneider and C.pinnatifidaBunge fruits for antioxidant,anti-alpha-glucoside,and antiinfl ammatory activities[J].Food Sci Biotechnol,2010,19(3):769-775.
[24]Wang H,Zhang ZS,Guo Y,et al.Hawthorn fruit increases the antioxidant capacity and reduces lipid peroxidation in senescence-accelerated mice[J].Eur Food Res and Technol,2011,232(5):743-751.
[25]肖焕,张嘉乐,崔升淼.山楂叶提取物泡腾片成型工艺的研究[J].中南药学,2010,8(3):202-204.
基本信息:
中图分类号:R285.5
引用信息:
[1]于蓓蓓,闫雪生,孙丹丹.山楂药理作用及其机制研究进展[J].中南药学,2015,13(07):745-748.
基金信息:
山东省中医药科技发展计划项目(No.2013-114)
2015-07-20
2015-07-20