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全蝎为蛛形纲蝎目钳蝎科昆虫,为息风平肝的要药,味辛、平,有毒。其药用历史悠久,具息风镇痉、通络止痛、攻毒散结之功效,主要用于治疗风湿、癫痫、中风、慢性疼痛等疾病。其主要活性成分为蝎毒、甾体衍生物、生物碱等。全蝎具镇痛抗炎、抗癌、抗癫痫、抗惊厥、抗凝、抗菌、促生长、提高免疫力等药理作用。本研究对全蝎化学成分、药理作用进行综述,以期为全蝎的深入研究和开发利用提供参考。
Abstract：Scorpion is an insect of Buthus martensii Karsch.It is an essential medicine for suppressing hyperactive liver and calming the endogenous wind.The flavour of Scorpion is pungent and it is mild-natured and poisonous.It has a long history of medicine usage,calming the endogenous wind and relieving the spasm.It can also activate the meridians to stop pain,attack poison and disperse knots.It is mainly used for rheumatim,epilepsy,stroke,chronic pain and other diseases.The major active components include buthotoxin,steroid derivatives,alkaloids,etc.It has analgesic,anti-inflammatory,anti-cancer,antiepileptic,anticonvulsant,anticonvulsant,antibacterial,growth promoting,immune enhancing and other pharmacological effects.The chemical constituents and pharmacological effects of Scorpion are reviewed in this study,which is expected to provide references for the further research and development of Scorpion.
[1]中国药典2015年版.一部[S].2015:143.
[2]唐·韩保升.蜀本草[M].合肥:安徽科学技术出版社,2005:211.
[3]宋·卢多逊.开宝本草(辑复本)[M].合肥:安徽科学技术出版社,1998:13.
[4]明·李时珍.本草纲目[M].北京:光明日报出版社,2013:681.
[5]马存德,王二欢,杨娟英,等.全蝎药材市场流通现状调查及展望[J].中国现代中药,2017,19(5):725-728.
[6]国家药品监督管理局药品查询.http://qy1.cfda.gov.cn.
[7]郝丽莉,刘淑兰.中药全蝎的研究进展[J].中医药学报,1994,36(5):49-55.
[8]刘应泉,卞慕唐,李畅开.蜈蚣蝎子油的化学成分研究[J].中国药学杂志,1983,18(6):27-28.
[9]王燕平,吕欣然.东亚钳蝎蝎毒分离纯化及药理作用的研究进展[J].中草药,2000,31(1):59-61.
[10]Possani LD,Seliso KB,Gurrola GB.Structure and function of Scorpion toxins affecting K+channels[J].Biochim Biophys Acta,1999,15(16):15-40.
[11]吴福林,董庆海,王涵,等.中药全蝎研究进展[J].辽宁中医药大学学报,2018,20(12):108-111.
[12]汪丽.东亚钳蝎毒镇痛活性肽Ⅴ(SAPⅤ)的分离纯化及部分性质研究[D].沈阳:沈阳药科大学,2006.
[13]张荒生,王进军.中药全蝎的药理研究进展[J].中国中医急症,2007,16(2):224-226.
[14]曹征宇.东亚钳蝎蝎毒多肽的分离纯化,结构鉴定,活性测定以及基因表达研究[D].北京:中国协和医科大学,2004.
[15]曹俊娜,王蕾,刘文第.蝎毒素结构与功能研究进展[J].河南中医学院学报,2009,24(3):118-120.
[16]何嘉进,刘霞,吉永华.蝎毒素的核磁共振结构解析[J].榆林学院学报,2017,27(2):62-65.
[17]Andrea RCC,Timoteo OP,Norberto CNE,et al.Structural and functional characterization of toxic peptides purified from the venom of the Colombian Scorpion Tityus macrochirus[J].Toxicon,2019,25(9):169.
[18]高婷,尹卫平.基于蛛形纲节肢动物药用价值及抗菌活性成分的研究[D].洛阳:河南科技大学.2012.
[19]Gao J,Yin W,Gao T.Two bioactive compounds from the Chinese Scorpion Buthusmartensii Karsch[J].Nat Prod Res,2014,28(10):698-703.
[20]张协光,孙天宇,肖伟敏.HPLC法同时测定植物样品中3种甾醇含量[J].食品工业,2019,40(1):327-330.
[21]艾双艳.全蝎和两面针化学成分研究[D].北京:天津理工大学,2012.
[22]刘华清.节肢动物地龙和全蝎抗菌化学成分研究[D].洛阳:河南科技大学,2018.
[23]郭晓锋.几种胆甾醇衍生物的合成工艺研究[D].哈尔滨:哈尔滨理工大学,2014.
[24]张岳,赵岩,蔡恩博,等.胆甾醇的结构修饰与生物活性研究进展[J].食品安全质量检测学报,2016,7(2):693-700.
[25]周柏松,杨娜,李雅萌.顶空固相微萃取-气相色谱-质谱联用检测全蝎的挥发性成分[J].特产研究,2018,40(2):52-55.
[26]王放,王显伦.食品营养保健及技术[M].北京:中国轻工业出版社,1997:7-100.
[27]唐海滨.全蝎临床应用的理论研究[D].济南:山东中医药大学,2013.
[28]杨芹,陶瑞,王鸿超.基于气相色谱-质谱联用技术的蝎子中脂肪酸与氨基酸的同时提取与分析[J].中国食品学报,2016,16(10):174-182.
[29]刘凯娜,王晓云,潘赢.全蝎质量评价及标准提高研究[J].中国现代中药,2017,19(2):209-213.
[30]梁琨,安叔,尤丽莎,等.柱前衍生化 RP-HPLC法测定中药全蝎中16种氨基酸含量[J].中国新药杂志,2014,23(6):716-200.
[31]Ferreira CF,Bernardi JR,Silva DC,et al.Mitochondrial and oxidative stress aspects in hippocampus of rats submitted to dietary n-3 polyunsaturated fatty acid deficiency after exposure to early stress[J].Neurochem Res,2015,40(9):1870-1881.
[32]Uchiyama K,Nakamura M,Odahara S,et al.N-3 polyunsaturated fatty acid diet therapy for patients with inflammatory bowel disease[J].Inflamm Bowel Dis,2010,16(10):1696-1707.
[33]刘应泉,卞慕唐,李畅开.蜈蚣蝎子油的化学成分研究[J].药学通报,1983,18(6):27-28.
[34]王洪平.全蝎中脂溶性化学成分的研究[D].济南:山东中医药大学,2010.
[35]覃小丽.人乳脂替代品的制备及质量评价的研究[D].广州:华南理工大学,2013.
[36]马西武,林敬明.全蝎不同部位的宏量和微量元素含量比较[J].广东微量元素科学,2000,7(7):54-58.
[37]蔡雪梅,张勇.全蝎种4种微量元素的形态分析[J].理化检验(化学分册),2011,47(5):523-524.
[38]刘丽芳,金蓉鸾,徐国钧.HPLC法测定10种动物药中尿嘧啶、黄嘌呤、次黄嘌呤、脲苷的含量[J].中国中药杂志,1999,19(2):73-76,124.
[39]田晓然,付廷明,郭立玮.HPLC同时测定全蝎不同工艺提取物中5种核苷类化合物含量[J].中国实验方剂学杂志,2013,19(8):13-16.
[40]张盼盼,贾伟,焦方文,等.全蝎蛋白抗肿瘤活性研究[J].中南药学,2017,15(8):1069-1071.
[41]焦方文,王利娜,王颖,等.全蝎酶解产物成分分析及抗肿瘤活性研究[J].食品与药品,2016,18(3):186-189.
[42]王聪聪,李峰,史磊.全蝎加工提取和含量测定方法研究进展[J].山东中医杂志,2015,34(1):77-79.
[43]焦方文,王利娜,王颖,等.全蝎酶解产物成分分析及抗肿瘤活性研究[J].食品与药品,2016,18(3):186-189.
[44]章红燕,何福根,王奇.全蝎抗肿瘤作用机制及临床应用研究进展[J].中国药业,2013,22(1):95-96.
[45]李洋,杜文东.全蝎抗肿瘤作用研究[J].长春中医药大学学报,2012,28(1):171-172.
[46]Petricevich VL,Cruz AH,Coronas FIV,et al.Toxin gammafrom Tityus serrulatus Scorpion venom plays an essen-tial role in immunomodulation of macrophages[J].Toxicon,2007,50(5):666-675.
[47]梁益,孙红斌,喻良,等.全蝎醇提物对慢性癫痫模型大鼠海马 GFAP mRNA 表达的影响[J].中国药房,2012,23(43):4033-4036.
[48]李冬冬,宫瑾,李雪飞,等.全蝎抗癫痫发作敏感性的阿片肽机制[J].中国微生态学杂志,1999,11(2):75-77.
[49]Zhang JH,Hua ZC,Xu Z,et al.Expression of anti-neuroexcitation peptide(ANEP)of Scorpion Buthus martensii Karsch in Escherichia coli[J].Prep Biochem Biotechnol,2001,31(1):49-57.
[50]Zhou XH,Yang D,Zhang JH,et al.Purification and N-terminal partial sequence of anti-epilepsy peptide from venom of the Scorpion Buthus martensii Karsch[J].Biochem J,1989,257(2):509.
[51]Wang Z,Wang W,Shao Z,et al.Eukaryotic expression and purification of anti-epilepsy peptide of Buthus martensii Karsch and its protein interactions[J].Mol Cell Biochem,2009,330(2):97-104.
[52]孔成诚,张传标,方成武,等.不同提取方法全蝎镇痛、镇静、抗惊厥作用的考察[J].中国医药科学,2012,2(4):39-41.
[53]毕国民,宋志勇,张金凤,等.天蝎安痫胶囊对小鼠急性癫痫的影响[J].湖南中医杂志,2017,33(6):157-159.
[54]邹英杰,王骥超,李志飞.全蝎蜈蚣对抽动症模型小鼠行为及单胺类神经递质的影响[J].中华中医药学刊,2016,34(2):434-437.
[55]郝晓云,彭延吉,肖长江.全蝎提取液对血液凝固的影响[J].血栓与止血学,2004,7(4):158-159.
[56]赵检英,石雕,谭茜,等.全蝎纯化液对实验性动脉血栓形成t-PA、PAI-1的影响[J].中西医结合心脑血管病杂志,2012,10(2):75-76.
[57]吴萍,谭茜,罗亚君,等.全蝎纯化液对凝血酶诱导血管内皮细胞释放NO、TFPI及表达TF的影响[J].中西医结合心脑血管病杂志,2013,11(10):1227-1228.
[58]易小民.全蝎纯化液对凝血酶诱导血管内皮细胞释放作用的影响[D].长沙:湖南中医药大学,2011.
[59]Valianpour F,Wanders RJA,Overmars H,et al.Linoleic acid supplemention of Barth syndrome fibroblasts restores cardiolipin levels:Implications for treatment[J].J Lipid Res,2003,44(3):560-566.
[60]刘霞,任可可,白占涛.陕北产东亚钳蝎毒液和体液的体外抑菌活性[J].延安大学学报(自然科学版),2016,35(2):55-58.
[61]Cao L,Li Z,Zhang,et al.StCT2,a new antibacterial peptide characterized from the venom of the Scorpion Scorpiops tibetanus[J].Peptides,2012,36(2):213-220.
[62]Zeng XC,Wang SX,Nie Y,et al.Characterization of BmKbpp,a multifunctional peptide from the Chinese Scorpion Mesobuthus martensii Karsch:Gaining insight into a new mechanism for the functional diversification of Scorpion venom peptides[J].Peptides,2012,33(1):44-51.
[63]Cao LY.Antimicrobial activity and mechanism of a Scorpion venom peptide derivative in vitro and in vivo[A]//2012年鄂粤微生物学学术年会[C].武汉:武汉微生物学会,2012:44.
[64]Arpornsuwan T,Buasakul B,Jaresitthikunchai J,et al.Potent and rapid antigonococcal activity of the venom peptide BmKn2 and its derivatives against different Maldi biotype of multidrug-resistant Neisseria gonorrhoeae[J].Peptides,2014,3(5):315-320.
[65]刘丽,傅伟龙,林涛,等.东亚钳蝎提取物对小鼠生长及血清IGF-I、FT3 浓度的影响[J].华南农业大学学报,2002,23(4):87-88.
[66]白洁,江华,李强,等.蝎毒素对人T淋巴细胞系Jurkat E6-1细胞增殖的影响[J].时珍国医国药,2010,21(12):3112-3113.
[67]韩雪飞,徐霞,申庆红,等.蝎毒素Ⅳ丹离纯化研究[J].河南医科大学报,1996,31(3):1-4.
[68]李海燕,杨佩兰,黄海茵,等.全蝎-蜈蚣药对对哮喘模型大鼠气道炎症及气道重塑的影响[J].中国实验方剂学杂志,2013,19(1):206-210.
[69]靳铁飞,吴萍,谭茜,等.全蝎纯化液对内毒素休克大鼠TF、TFPI 及 TNF 的影响[J].中西医结合心脑血管病杂志,2013,11(2):179-180.
[70]Wang XG,Zhu DD,Li N,et al.Scorpion venom heat-resistant peptide is neuroprotective against cerebral ischemia-reperfusion injury in association with the NMDA-MAPK pathway[J].Neurosci Bull,2019,57(8):876-883.
基本信息:
中图分类号:R285;R284.1
引用信息:
[1]杨志欣,汲丽丽,刘慧,等.全蝎化学成分和药理作用的研究进展[J].中南药学,2020,18(09):1523-1529.
基金信息:
黑龙江省自然科学基金(No.H2016057);黑龙江省自然科学基金项目(No.H2017066)
2020-05-18
2020-05-18
2020-05-18