| 97 | 0 | 126 |
| 下载次数 | 被引频次 | 阅读次数 |
系统性红斑狼疮（SLE）是一种以免疫失衡、慢性炎症和多器官损害为特征的复杂自身免疫病。随着研究的深入，药食同源中药凭借其安全性高、适宜长期使用及多成分-靶点的协同优势，在SLE防治中潜力凸显。本文在系统检索近年相关文献的基础上，总结药食同源中药在改善免疫指标、调控炎症网络、缓解肾脏损伤等方面的临床证据；梳理其通过NF-κB、JAK/STAT、MAPK等信号通路以及Th17/Treg平衡重建所形成的多靶点调控机制；重点阐述其在免疫代谢重编程、表观遗传修饰、药代动力学协同作用及肠道屏障改善等多维层面上的新进展；并整合质量控制、新型生物标志物和中医证型分层等最新研究方向。旨在构建药食同源中药干预SLE的系统性证据链，为未来精准化、长期化的干预策略提供参考。
Abstract：Systemic lupus erythematosus(SLE) is a complex autoimmune disease characterized by immune dysregulation, chronic inflammation, and multiorgan involvement. Food-medicine homologous herbs have attracted growing attention because of their favorable safety profile for longterm use and multi-component and multi-target regulatory properties. This review summarized recent clinical evidence suggesting that these herbs might improve immunological parameters, alleviate renal injury, reduce inflammatory responses, and decrease disease activity. These effects are associated with the regulation of key signaling pathways, including NF-κB, JAK/STAT and MAPK, restoration of the Th17/Treg balance, and modulation of immunometabolic and epigenetic abnormalities. In addition, recent progress in pharmacokinetic synergy, intestinal barrier protection, and multitarget network pharmacology was also outlined. Furthermore, emerging quality-control approaches, candidate biomarkers, and syndrome-based treatment frameworks were discussed. Overall, this paper provided an overview of the potential role of food-medicine homologous herbs in SLE intervention the development of more precise and sustainable intervention strategies.
[1]张令悦，苏励.中药组方治疗系统性红斑狼疮的临床研究进展[J].中成药，2025,47(1):170-174.
[2]王子涵，陈艳宇，崔勇，等.中医药临床优势病种探讨——系统性红斑狼疮[J].中国实验方剂学杂志，2025,31(13):263-269.
[3]张莹莹，束庆，葛佳佳，等.系统性红斑狼疮患者内源性激素对免疫系统的影响[J].中国免疫学杂志，2023,39(7):1525-1531.
[4]杨帆，沈俊逸，蔡辉，等.人参皂苷Rb1对系统性红斑狼疮患者T淋巴细胞活化的影响[J].实用药物与临床，2021,24(5):418-422.
[5]Zhan KJ,Chen S,Ji L,et al. Network pharmacology to unveil the mechanism of Astragali Radix in the treatment of lupus nephritis via PI3K/AKT/mTOR pathway[J]. Sci Rep,2024,14(1):25983.
[6]王慧莲，孟庆良，李松伟，等.茯苓多糖对SLE患者Th17/Treg平衡的影响[J].中国病理生理杂志，2017,33(8):1514-1519.
[7]黄继勇，范永升.蒲公英治疗系统性红斑狼疮经验[J].中华中医药杂志，2013,28(7):2037-2039.
[8]清怡，邹旭辉，汪凡，等.基于NF-κB/NLRP3炎症小体探讨黄芪甲苷Ⅳ对系统性红斑狼疮模型小鼠免疫功能的影响[J].广州中医药大学学报，2024,41(9):2433-2441.
[9]汪嘉俊，王泽萍，王雪莲，等.山茱萸化学成分和药理作用研究进展[J].中草药，2025,56(3):1088-1103.
[10]杨菊花，李常学，郑璐瑶，等.山茱萸-山药水提物改善免疫功能[J].中药药理与临床，2024,40(11):34-40.
[11]Li ZY,Gan HL,Ji K,et al. Protopanaxadiol improves lupus nephritis by regulating the PTX3/MAPK/ERK1/2pathway[J]. J Nat Med,2024,78(3):474-487.
[12]黄自坤，高玉洁，罗清，等.血浆环状RNA hsacirc-0034398在系统性红斑狼疮中的表达和意义[J].中国免疫学杂志，2023,39(1):109-115.
[13]武上雯，李桓，龚晓红，等.基于网络药理学探讨补肺通痹汤治疗系统性红斑狼疮肺间质病变的作用机制及关键通路的验证[J].北京中医药大学学报，2024,47(9):1256-1271.
[14]王莹，环磷酰胺、泼尼松联合枸杞多糖治疗狼疮性肾炎77例临床观察[J].中国民族民间医药，2019,28(23):83-8588.
[15]黄佳静，房悦，王妍妍，等.不同等级茯苓块、茯苓片的外观性状与内在成分的相关性研究[J].中南药学，2025,23(1):78-83.
[16]谢士敏，周长征.蒲公英药理作用及临床应用研究进展[J].辽宁中医药大学学报，2020,22(5):138-142.
[17]张怡情，黄清霞，冯旭，等.蒲公英化学成分、药理作用及质量标志物预测分析[J].辽宁中医药大学学报，2025,27(2):59-67.
[18]李力，张瑞仙.系统性红斑狼疮患者血管内皮细胞损伤影响因素研究进展[J].医学研究杂志，2024,53(6):168-171.
[19]Wang Y,Bu P,Deng Y,et al. Research progress on traditional Chinese medicine compounds in autoimmune-related skin diseases[J]. Front Immunol,2025,16:1629288.
[20]周央中，赵久良，田新平，等.《中国系统性红斑狼疮诊疗指南（2025版）》解读[J].协和医学杂志，2025,16(5):1193-1198.
[21]孙艳秋，刘健，贺明玉，等.基于数据挖掘和网络药理学方法探讨中医药治疗系统性红斑狼疮的用药规律和作用机制[J].山西中医药大学学报，2024,25(8):893-901.
[22]刘思，宋娟，洋雯茜，等.枸杞多糖结构特征、生物活性及其降解研究进展[J].中草药，2025,56(4):1440-1455.
[23]D?rner T,Jacobi A M,Lee J,et al. Abnormalities of B cell subsets in patients with systemic lupus erythematosus[J].J Immunol Methods,2011,363(2):187-197.
[24]韩夏夏，蒋扬，顾霜霜，等.系统性红斑狼疮患者免疫细胞代谢通路转录组分析[J].上海交通大学学报（医学版），2022,42(9):1197-1207.
[25]Xie XD,Tang M,Yi SL,et al.Polysaccharide of Asparagus cochinchinensis(Lour.)merr regulates macrophage immune response and epigenetic memory through TLR4-JNK/p38/ERK signaling pathway and histone modification[J]. Phytomedicine,2024,124:155294.
[26]Cheng Y,Xie Y,Ge JC,et al. Structural characterization and hepatoprotective activity of a galactoglucan from Poria cocos[J]. Carbohydrate Polymers,2021,263:117979.
[27]Duan Y,Huang J,Sun M,et al. Poria cocos polysaccharide improves intestinal barrier function and maintains intestinal homeostasis in mice[J]. Int Biol Macromol,2023,249:125953.
[28]张凤，张甜甜，涂东珠，等.中草药抑制CYP3A4的效应物质研究进展[J].遵义医科大学学报，2021,44(5):559-574.
[29]Wang HN,Guo F,Wang M,et al. The Effect of TLR9,MyD88,and NF-κB p65 in Systemic Lupus Erythematosus[J]. Evid Based Complement Alternat Med,2022,2022(1):6830366.
[30]Yu H,Lin LB,Zhang ZQ,et al. Targeting NF-κB pathway for the therapy of diseases:mechanism and clinical study[J]. Signal Transduct Target Ther,2020,5(1):209.
[31]Mussbacher M,Derler M,Basílio J,et al. NF-κB in monocytes and macrophages–an inflammatory master regulator in multitalented immune cells[J]. Front Immunol,2023,14:1134661.
[32]Noor HB,Mou NA,Salem L,et al. Anti-inflammatory property of AMP-activated protein kinase[J]. Anti-Inflamm Allergy Agents Med Chem,2020,19(1):2-41.
[33]Hu XY,Li J,Fu MR,et al. The JAK/STAT signaling pathway:from bench to clinic[J]. Signal Transduct Target Ther,2021,6(1):402.
[34]Nikolopoulos D,Parodis I.Janus kinase inhibitors in systemic lupus erythematosus:implications for tyrosine kinase 2 inhibition[J]. Front Med,2023,10:1217147.
[35]Imbaby S,Matsuda N,Tomita K,et al. Beneficial effect of STAT3 decoy oligodeoxynucleotide transfection on organ injury and mortality in mice with cecal ligation and puncture-induced sepsis[J]. Sci Rep,2020,10(1):15316.
[36]Zhang X,Bian ZY,Zhang JY,et al. Research progress on the mechanism of anti-myocardial infarction effect and clinical application of effective components of Salvia miltiorrhiza[J]. Med Chem Res,2024,33(2):239-253.
[37]张之燕，黄志敏，江旖旎，等.积雪草多靶点治疗系统性红斑狼疮的可行性思考[J].广西医学，2019,41(14):1820-1823.
[38]国家药品监督管理局.中药质量标准制定技术要求（试行）[S].北京：国家药品监督管理局，2020.
[39]Carling D,Mayer FV,Sanders MJ,et al. AMP-activated protein kinase:nature's energy sensor[J]. Nat Chem Biol,2011,7(8):512-518.
[40]胡金川，陈松楠，张立敏，等. T细胞CD4+/CD8+比值及CD4、CD8编码基因单核苷酸多态性与系统性红斑狼疮的关联研究[J].标记免疫分析与临床，2022,29(7):1135-1141.
[41]Siegel CH,Sammaritano LR. Systemic lupus erythematosus:a review[J]. JAMA,2024,331(17):1480-1491.
[42]冯彦飞，杨小杰，强建红，等.系统性红斑狼疮患者血清miR-125b-5p水平与Th1/Th2细胞、Th17/Treg细胞失衡的相关性[J].检验医学与临床，2025,22(2):227-231.
[43]杨建敏，王怡佳，杨惠芳，等.系统性红斑狼疮患者淋巴细胞亚群和TLR9及TLR2预测继发真菌感染的临床价值[J].中华医院感染学杂志，2025,35(4):523-527.
[44]Doglio M,Ugolini A,Bercher-Brayer C,et al. Regulatory T cells expressing CD19-targeted chimeric antigen receptor restore homeostasis in systemic lupus erythematosus[J].Nat Commun,2024,15(1):2542.
[45]杨骥，杨雪，汪路曼，等. Th17细胞对调节性B细胞的分化和IL-10分泌的影响[J].临床皮肤科杂志，2019,48(12):725-728.
基本信息:
中图分类号:R285
引用信息:
[1]党安琪,任蓁,那强,等.药食同源中药干预系统性红斑狼疮的研究进展和作用机制[J].中南药学().
基金信息:
国家自然科学基金资助项目(No.81373537)
2026-07-03
2026-07-03
2026-07-03