中国医学科学院北京协和医学院药用植物研究所;
间质性膀胱炎(IC)是一种具有明显症状的慢性顽固性泌尿系统疾病,目前临床上通常对症状改善不明显的患者进行膀胱内给药治疗。然而,尿路上皮屏障、药物随尿液排出、患者顺应性不佳等因素严重影响药物在膀胱内的治疗效果。本文从IC的发病机制、现有疗法及新型膀胱内给药制剂进展三方面进行综述,以期为膀胱内给药疗法在治疗IC方面的应用提供参考和理论依据。
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[1]Akiyama Y,Sonehara K,Maeda D,et al.Genome-wide association study identifies risk loci within the major histocompatibility complex region for Hunner-type interstitial cystitis[J].Cell Rep Med,2023,4(7):101114.
[2]Fall M,Nordling J,Cervigni M,et al.Hunner lesion disease differs in diagnosis,treatment and outcome from bladder pain syndrome:an ESSIC working group report[J].Scand J Urol,2020,54(2):91-98.
[3]Wein AJ.Re:update on the pathophysiology of interstitial cystitis/bladder pain syndrome[J].J Urol,2020,204(3):625.
[4]Homma Y,Akiyama Y,Kim JH,et al.Definition change and update of clinical guidelines for interstitial cystitis and bladder pain syndrome[J].Low Urin Tract Symptoms,2024,16(5):e12532.
[5]Homma Y,Akiyama Y,Tomoe H,et al.Clinical guidelines for interstitial cystitis/bladder pain syndrome[J].Int J Urol,2020,27(7):578-589.
[6]Li J,Yi XY,Ai JZ.Broaden horizons:the advancement of interstitial cystitis/bladder pain syndrome[J].Int J Mol Sci,2022,23(23):14594.
[7]Offiah I,McMahon SB,O’Reilly BA.Interstitial cystitis/bladder pain syndrome:diagnosis and management[J].Int Urogynecol J,2013,24(8):1243-1256.
[8]Clemens JQ,Meenan RT,Rosetti MCO,et al.Prevalence and incidence of interstitial cystitis in a managed care population[J].J Urol,2005,173(1):98-102.
[9]Dinis S,De Oliveira JT,Pinto R,et al.From bladder to systemic syndrome:concept and treatment evolution of interstitial cystitis[J].Int J Womens Health,2015,7:735-744.
[10]Akiyama Y,Maeda D,Katoh H,et al.Molecular taxonomy of interstitial cystitis/bladder pain syndrome based on whole transcriptome profiling by next-generation RNA sequencing of bladder mucosal biopsies[J].J Urol,2019,202(2):290-300.
[11]Wyndaele JJJ,Riedl C,Taneja R,et al.GAG replenishment therapy for bladder pain syndrome/interstitial cystitis[J].Neurourol Urodyn,2019,38(2):535-544.
[12]Patnaik SS,Laganà AS,Vitale SG,et al.Etiology,pathophysiology and biomarkers of interstitial cystitisumpainful bladder syndrome[J].Arch Gynecol Obstet,2017,295(6):1341-1359.
[13]Lazzeri M,Hurle R,Casale P,et al.Managing chronic bladder diseases with the administration of exogenous glycosaminoglycans:an update on the evidence[J].Ther Adv Urol,2016,8(2):91-99.
[14]Keller JJ,Chen YK,Lin HC.Comorbidities of bladder pain syndrome/interstitial cystitis:a population-based study[J].BJU Int,2012,110(11C):E903-E909.
[15]Jin XW,Liu BK,Zhang X,et al.Establishment of a novel autoimmune experimental model of bladder pain syndrome/interstitial cystitis in C57BL/6 mice[J].Inflammation,2017,40(3):861-870.
[16]Peng L,Jin X,Li BY,et al.Integrating single-cell RNA sequencing with spatial transcriptomics reveals immune landscape for interstitial cystitis[J].Signal Transduct Target Ther,2022,7(1):161.
[17]Su F,Zhang W,Meng LF,et al.Multimodal single-cell analyses outline the immune microenvironment and therapeutic effectors of interstitial cystitis/bladder pain syndrome[J].Adv Sci(Weinh),2022,9(18):2106063.
[18]Liu HT,Kuo HC.Biomarkers for patients with interstitial cystitis/bladder pain syndrome[J].Urol Sci,2015,26(4):225-229.
[19]Jacobs BL,Smaldone MC,Tyagi V,et al.Increased nerve growth factor in neurogenic overactive bladder and interstitial cystitis patients[J].Can J Urol,2010,17(1):4989-4994.
[20]Parsons CL,Argade S,Evans RJ,et al.Role of urinary cations in the etiology of interstitial cystitis:a multisite study[J].Int J Urol,2020,27(9):731-735.
[21]Keay SK,Zhang CO.Abnormal Akt signalling in bladder epithelial cell explants from patients with interstitial cystitis/bladder pain syndrome can be induced by antiproliferative factor treatment of normal bladder cells[J].BJU Int,2016,118(1):161-172.
[22]Mormone E,Cisternino A,Capone L,et al.The model of interstitial cystitis for evaluating new molecular strategies of interstitial regeneration in humans[J].Int J Mol Sci,2024,25(4):2326.
[23]Wróbel A,Serefko A,Bańczerowska-Górska M,et al.Intravesical administration of blebbistatin prevents cyclophosphamide-induced toxicity of the urinary bladder in female Wistar rats[J].Neurourol Urodyn,2019,38(4):1044-1052.
[24]Ni B,Chen ZS,Shu L,et al.Nrf2 pathway ameliorates bladder dysfunction in cyclophosphamide-induced cystitis via suppression of oxidative stress[J].Oxid Med Cell Longev,2021:4009308.
[25]Li J,Luo H,Dong XY,et al.Therapeutic effect of urine-derived stem cells for protamine/lipopolysaccharide-induced interstitial cystitis in a rat model[J].Stem Cell Res Ther,2017,8(1):107.
[26]Mohammad A,Laboulaye MA,Shenhar C,et al.Mechanisms of oxidative stress in interstitial cystitis/bladder pain syndrome[J].Nat Rev Urol,2024,21(7):433-449.
[27]Windgassen S,McKernan L.Cognition,emotion,and the bladder:psychosocial factors in bladder pain syndrome and interstitial cystitis(BPS/IC)[J].Curr Bladder Dysfunct Rep,2020,15(1):9-14.
[28]Liu X,Yang Y,Gao Y,et al.Estrogen inhibits bladder overactivity in rats with cyclophosphamide-induced cystitis via downregulating the expression of P2X3 receptors in bladder epithelium cells[J].Neurourol Urodyn,2022,41(1):174-187.
[29]Hanno PM,Erickson D,Moldwin R,et al.Diagnosis and treatment of interstitial cystitis/bladder pain syndrome:AUA guideline amendment[J].J Urol,2015,193(5):1545-1553.
[30]Clemens JQ,Erickson DR,Varela NP,et al.Diagnosis and treatment of interstitial cystitis/bladder pain syndrome[J].J Urol,2022,208(1):34-42.
[31]Van Ophoven A,Pokupic S,Heinecke A,et al.A prospective,randomized,placebo controlled,double-blind study of amitriptyline for the treatment of interstitial cystitis[J].J Urol,2004,172(2):533-536.
[32]Hertle L,Van Ophoven A.Long-term results of amitriptyline treatment for interstitial cystitis[J].Aktuelle Urol,2010,41(S1):S61-S65.
[33]Thilagarajah R,Witherow RO,Walker MM.Oral cimetidine gives effective symptom relief in painful bladder disease:a prospective,randomized,double-blind placebo-controlled trial[J].BJU Int,2001,87(3):207-212.
[34]Pearce WA,Chen R,Jain N.Pigmentary maculopathy associated with chronic exposure to pentosan polysulfate sodium[J].Ophthalmology,2018,125(11):1793-1802.
[35]Sairanen J,Tammela TL,Leppilahti M,et al.Cyclosporine A and pentosan polysulfate sodium for the treatment of interstitial cystitis:a randomized comparative study[J].J Urol,2005,174(6):2235-2238.
[36]Forrest JB,Payne CK,Erickson DR.Cyclosporine A for refractory interstitial cystitis/bladder pain syndrome:experience of 3 tertiary centers[J].J Urol,2012,188(4):1186-1191.
[37]Palugan L,Cerea M,Cirilli M,et al.Intravesical drug delivery approaches for improved therapy of urinary bladder diseases[J].Int J Pharm X,2021,3:100100.
[38]Perez-Marrero R,Emerson LE,Feltis JT.A controlled study of dimethyl sulfoxide in interstitial cystitis[J].J Urol,1988,140(1):36-39.
[39]Parsons CL,Housley T,Schmidt JD,et al.Treatment of interstitial cystitis with intravesical heparin[J].Br J Urol,1994,73(5):504-507.
[40]Nickel JC,Jain P,Shore N,et al.Continuous intravesical lidocaine treatment for interstitial cystitis/bladder pain syndrome:safety and efficacy of a new drug delivery device[J].Sci Transl Med,2012,4(143):143ra100.
[41]Kocatürk H,Atasoy N,Bedir F,et al.Questionnaire-guided evaluation of the effectiveness of long-term intravesical 0.2% chondroitin sulfate therapy in interstitial cystitis[J].Int Urogynecol J,2021,32(5):1293-1298.
[42]Giberti C,Gallo F,Cortese P,et al.Combined intravesical sodium hyaluronate/chondroitin sulfate therapy for interstitial cystitis/bladder pain syndrome:a prospective study[J].Ther Adv Urol,2013,5(4):175-179.
[43]Matsuoka PK,Haddad JM,Pacetta AM,et al.Intravesical treatment of painful bladder syndrome:a systematic review and meta-analysis[J].Int Urogynecol J,2012,23(9):1147-1153.
[44]Kendall HJ,Schrijvers J,Heesakkers JPFA.Current position of neuromodulation for bladder pain syndrome/interstitial cystitis[J].Curr Opin Urol,2024,34(2):64-68.
[45]Shin JH,Park JH,Ryu CM,et al.Stem cell therapy for interstitial cystitis/bladder pain syndrome[J].Low Urin Tract Symptoms,2024,16(4):e12527.
[46]Kuo HC.Intravesical injections of autologous platelet-rich plasma for the treatment of refractory interstitial cystitis[J].Low Urin Tract Symptoms,2023,15(6):210-215.
[47]Majima T,Tyagi P,Dogishi K,et al.Effect of intravesical liposome-based nerve growth factor antisense therapy on bladder overactivity and nociception in a rat model of cystitis induced by hydrogen peroxide[J].Hum Gene Ther,2017,28(7):598.
[48]Hung FC,Kuo HC.Liposome-encapsulated botulinum toxin A in treatment of functional bladder disorders[J].Toxins,2022,14(12):838.
[49]Ma C,Zhong XF,Liu R,et al.Co-delivery of oxaliplatin prodrug liposomes with bacillus calmette-guérin for chemo-immunotherapy of orthotopic bladder cancer[J].J Control Release,2024,365:640-653.
[50]GuhaSarkar S,More P,Banerjee R.Urothelium-adherent,ion-triggered liposome-in-gel system as a platform for intravesical drug delivery[J].J Control Release,2017,245:147-156.
[51]Shawky S,Makled S,Awaad A,et al.Quercetin loaded cationic solid lipid nanoparticles in a mucoadhesive in situ gel-a novel intravesical therapy tackling bladder cancer[J].Pharmaceutics,2022,14(11):2527.
[52]Qi FG,Bao QQ,Hu P,et al.Mild magnetic hyperthermia-activated immuno-responses for primary bladder cancer therapy[J].Biomaterials,2024,307:122514.
[53]Cai XM,Ruan LF,Wang DQ,et al.Boosting chemotherapy of bladder cancer cells by ferroptosis using intelligent magnetic targeting nanoparticles[J].Colloid Surface B,2024,234:113664.
[54]Ways TMM,Lau WM,Khutoryanskiy VV.Chitosan and its derivatives for application in mucoadhesive drug delivery systems[J].Polymers,2018,10(3):267.
[55]Kong N,Zhang RN,Wu GW,et al.Intravesical delivery of KDM6A-mRNA via mucoadhesive nanoparticles inhibits the metastasis of bladder cancer[J].Proc Natl Acad Sci U S A,2022,119(7):e2112696119.
[56]Du HF,Yin HY,Qin YH,et al.Subcellular nanobionic liposome with high zeta potential enhances intravesical adhesion and drug delivery[J].ACS Nano,2024,18(4):3583-3596.
[57]Lin TS,Zhao XZ,Zhang YF,et al.Floating hydrogel with self-generating micro-bubbles for intravesical instillation[J].Materials,2016,9(12):1005.
[58]Jensen MM,Jia W,Schults AJ,et al.Temperature-responsive silk-elastinlike protein polymer enhancement of intravesical drug delivery of a therapeutic glycosaminoglycan for treatment of interstitial cystitis/painful bladder syndrome[J].Biomaterials,2019,217:119293.
[59]Jing WQ,Chen C,Wang GY,et al.Metabolic modulation of intracellular ammonia via intravesical instillation of nanoporter-encased hydrogel eradicates bladder carcinoma[J].Adv Sci,2023,10(12):e2206893.
[60]Guo W,Liu HC,Zhang JX,et al.Preparation and characterization of a novel composite acellular matrix/hyaluronic acid thermosensitive hydrogel for interstitial cystitis/bladder pain syndrome[J].J Biomed Mater Res A,2024,112(3):449-462.
[61]Qiu XF,Cao K,Lin TS,et al.Drug delivery system based on dendritic nanoparticles for enhancement of intravesical instillation[J].Int J Nanomedicine,2017,12:7365-7374.
[62]Ambrosio L,Argenziano M,Cucci MA,et al.Carbosilane dendrimers loaded with siRNA targeting Nrf2 as a tool to overcome cisplatin chemoresistance in bladder cancer cells[J].Antioxidants(Basel),2020,9(10):993.
[63]Simó C,Serra-Casablancas M,Hortelao AC,et al.Urease-powered nanobots for radionuclide bladder cancer therapy[J].Nat Nanotechnol,2024,19(4):554-564.
[64]Cong ZQ,Tang SS,Xie LM,et al.Magnetic-powered Janus cell robots loaded with oncolytic adenovirus for active and targeted virotherapy of bladder cancer[J].Adv Mater,2022,34(26):e2201042.
[65]Tang SS,Tang DT,Zhou HH,et al.Bacterial outer membrane vesicle nanorobot[J].Proc Natl Acad Sci U S A,2024,121(30):e2403460121.
[66]Choi H,Cho SH,Hahn SK.Urease-powered polydopamine nanomotors for intravesical therapy of bladder diseases[J].ACS Nano,2020,14(6):6683-6692.
基本信息:
DOI:
中图分类号:R694.3
引用信息:
[1]李玉卓,郑依婷,廖永红.间质性膀胱炎及其膀胱内给药制剂研究进展[J].中南药学,2025,23(04):1036-1043.
基金信息:
国家自然科学基金项目(No.82173983)