刘涛,宗广楠,朱瑞,吴成军,陈建超,孙铁民

• 1:沈阳药科大学基于靶点的药物设计与研究教育部重点实验室制药工程学院
• 2:鲁南制药集团股份有限公司

摘要(Abstract)：

氨酰-tRNA合成酶(aminoacyl-tRNA synthetase,aaRS)在各种生物蛋白质的合成过程发挥了重要的作用,其专一性结合氨基酸的能力保证了生物体基因组的正确表达。与此同时,越来越多的研究表明其在胞外同样发挥着重要的生物学功能。因此,以aaRS为靶点的新药研究引起了越来越多的关注。本文从aaRS的结构出发,对其在细胞内外的生物功能以及在近几年药物研究中的应用进行概述。

关键词(KeyWords)： 氨酰-tRNA合成酶;蛋白质的合成;药物研发

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金青年项目(No.81903474)

作者(Author): 刘涛,宗广楠,朱瑞,吴成军,陈建超,孙铁民

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