羊角棉枝叶的化学成分研究Chemical constituents in the twigs and leaves of Alstonia mairei Lévl.
秦文秀,于硕,李畅,裴月湖,杨异卉
摘要(Abstract):
目的 研究鸡骨常山属羊角棉(Alstonia mairei Lévl.)枝叶中的化学成分。方法 羊角棉枝叶药材经95%乙醇提取得到提取物,再利用MCI凝胶柱进行初步分离,其中90%乙醇洗脱部位再利用各种柱色谱方法如硅胶、ODS、制备型高效液相色谱等进行化学组分的细致分离,最后通过核磁共振氢谱和碳谱对化合物进行结构鉴定。结果 从羊角棉中分离并鉴定了10个化合物,分别为四氢鸭脚木碱(1)、柯楠次碱(2)、拉兹马宁碱(3)、维洛斯明碱(4)、钩藤碱E(5)、19(S)-epimisiline(6)、antiquorin(7)、3β,5α,20-trihydroxy-15β-cinnamoyloxy-14-oxolathyra-6Z,12E-diene(8)、橘皮素(9)和丁香脂素(10)。结论 化合物5~9为首次从鸡骨常山属植物中分离鉴定,化合物2~4以及10为首次从羊角棉中分离鉴定,其中化合物1~6为单萜吲哚类生物碱。
关键词(KeyWords): 羊角棉;化学成分;吲哚类生物碱;鸡骨常山属
基金项目(Foundation):
作者(Author): 秦文秀,于硕,李畅,裴月湖,杨异卉
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